microRNA-125b-5p is a promising novel plasma biomarker for alveolar echinococcosis in patients from the southern province of Qinghai

BMC Infectious Diseases

Cao Deping¹  Jiang Bofan²  Pang Mingquan³  Zhang Yaogang³ 

[1] Department of Human Parasitology, Guilin Medical College, 541101, Guilin, Guangxi Zhuang Autonomous, China;The Department of Pathogenic Biology of Qinghai University Medical College, 810001, Xining, Qinghai Province, China;The Echinococcosis Key Laboratory of Affiliated Hospital of Qinghai University, 810001, Xining, Qinghai Province, China;

关键词: Echinococcus multilocularis;    Alveolar echinococcosis;    Biomarker;    hsa-miR-125b-5p;    Plasma;   

DOI  :  10.1186/s12879-021-05940-z

来源: Springer

【 摘 要 】

BackgroundAlveolar echinococcosis (AE) is caused by parasitic infection by Echinococcus multilocularis. Its diagnosis is usually based on clinical symptoms, ultrasound, and other imaging methods. MicroRNAs (miRNAs) play important roles in disease processes and can exist in a highly stable cell-free form in body fluids. It is important to identify specific, sensitive diagnostic markers for early diagnosis and evaluation of AE. In this study, we examined hsa-miR-125b-5p as a potential plasma biomarker of E. multilocularis infection.MethodsPlasma samples from patients with AE and healthy individuals were screened for the presence of five miRNAs using miRNA chips. We used quantitative polymerase chain reaction to measure miRNA expression levels in plasma and liver tissue samples from patients with AE.Resultshsa-miR-125b-5p was stably upregulated in the plasma and liver tissue samples from patients with AE.ConclusionsThe results suggest that hsa-miR-125b-5p may be a promising biomarker for early, non-invasive diagnosis of AE.

【 授权许可】

CC BY