The use of immunotherapy treatment in malignant pheochromocytomas/paragangliomas: a case report

Journal of Medical Case Reports

Gene Grant Finley¹  Saleha Rizwan¹  Robin Raquel Rodriguez¹  Khaled Alhamad¹ 

[1] Department of Medical Oncology, Allegheny General Hospital, 15212, Pittsburgh, PA, USA;

关键词: Pheochromocytomas;    Immunotherapy;    Oncology;    Rare tumors;    Off-label treatment options;    Case report;   

DOI  :  10.1186/s13256-021-02733-5

来源: Springer

【 摘 要 】

BackgroundPheochromocytomas are a subset of paragangliomas, which are a rare group of neural crest cell-derived tumors. Malignant cases of both pheochromocytomas and paragangliomas are even rarer, and currently there is no standard of care. This case report details the use of off-label immunotherapy and its efficacy in the management of the aforementioned tumor.Case presentationHerein is presented a case of a 60-year-old Caucasian female with a rare malignant pheochromocytoma. The tumor was determined to be unresectable because of involvement of surrounding organs. Radiation therapy was also not a viable option because of concerns over appreciable toxicity in relation to mass size. As there is no standard of care for malignant cases, the patient was started on chemotherapeutic agents but was soon shown to be intolerant to this treatment. As she was ineligible for several clinical trials, the patient was started on the off-label immunotherapeutic agents nivolumab and ipilimumab. Immunotherapy use resulted in decreased tumor size, improved quality of life, and reconsideration for radiation therapy.ConclusionsThe use of immunotherapy in pheochromocytoma in this patient clearly demonstrated substantial benefit, as she was able to be reconsidered for radiation therapy. Not only has the patient been tolerant of this treatment, but she has exhibited progression-free survival of over 20 months. As there is no current standard treatment for malignant pheochromocytomas, the success of its use in this patient lends support to the ongoing clinical trials regarding the use of immunotherapy in rare tumors, including pheochromocytomas.

【 授权许可】

CC BY