Optimization of contrast medium volume for abdominal CT in oncologic patients: prospective comparison between fixed and lean body weight-adapted dosing protocols

Insights into Imaging

Davide Bellini¹  Iacopo Carbone¹  Nicola Panvini¹  Marco Rengo¹  Paolo Anibaldi²  Benedetta Bracci³  Damiano Caruso³  Michela Polici³  Andrea Laghi³  Elisa Rosati³  Elsa Iannicelli³  Giulia Moltoni³  Domenico De Santis³  Marta Zerunian³  Elena Lucertini³ 

[1] Diagnostic Imaging Unit, Department of Medico-Surgical Sciences and Biotechnologies, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana, 1668, 04100, Latina, Italy;Hospital Direction and Clinical Departments, Sant’Andrea University Hospital, Via di Grottarossa, 1035-1039, 00189, Rome, Italy;Radiology Unit, Department of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome - Sant’Andrea University Hospital, Via di Grottarossa, 1035-1039, 00189, Rome, Italy;

关键词: Computed tomography;    Contrast media;    Lean body weight;    Oncologic imaging;    Abdomen;   

DOI  :  10.1186/s13244-021-00980-0

来源: Springer

【 摘 要 】

BackgroundPatient body size represents the main determinant of parenchymal enhancement and by adjusting the contrast media (CM) dose to patient weight may be a more appropriate approach to avoid a patient over dosage of CM. To compare the performance of fixed-dose and lean body weight (LBW)-adapted contrast media dosing protocols, in terms of image quality and parenchymal enhancement.ResultsOne-hundred cancer patients undergoing multiphasic abdominal CT were prospectively enrolled in this multicentric study and randomly divided in two groups: patients in fixed-dose group (n = 50) received 120 mL of CM while in LBW group (n = 50) the amount of CM was computed according to the patient’s LBW. LBW protocol group received a significantly lower amount of CM (103.47 ± 17.65 mL vs. 120.00 ± 0.00 mL, p < 0.001). Arterial kidney signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) and pancreatic CNR were significantly higher in LBW group (all p ≤ 0.004). LBW group provided significantly higher arterial liver, kidney, and pancreatic contrast enhancement index (CEI) and portal venous phase kidney CEI (all p ≤ 0.002). Significantly lower portal vein SNR and CNR were observed in LBW-Group (all p ≤ 0.020).ConclusionsLBW-adapted CM administration for abdominal CT reduces the volume of injected CM and improves both image quality and parenchymal enhancement.

【 授权许可】

CC BY