The increasing expression of GPX7 related to the malignant clinical features leading to poor prognosis of glioma patients

Chinese Neurosurgical Journal

Xin Chen¹  Penglei Yao¹  Zhendong Liu¹  Ruotian Zhang¹  Qiuyi Jiang¹  Quan Yang¹  Jianing Wu¹  Jiawei Yao¹  Shiguang Zhao²  Cheng Zhang³ 

[1] Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, 150001, Harbin, Heilongjiang Province, China;Key Colleges and Universities Laboratory of Neurosurgery in Heilongjiang Province, 150001, Harbin, Heilongjiang Province, China;Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, 150001, Harbin, Heilongjiang Province, China;Key Colleges and Universities Laboratory of Neurosurgery in Heilongjiang Province, 150001, Harbin, Heilongjiang Province, China;Department of Neurosurgery, The Pinghu Hospital of Shenzhen University, 518100, Shenzhen, Guangdong Province, China;Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, 150001, Harbin, Heilongjiang Province, China;North Broward Preparatory School, 7600 Lyons Rd, 33073, Coconut Creek, FL, USA;

关键词: GPX7;    Glioma;    Biomarker;    Survival;   

DOI  :  10.1186/s41016-021-00235-3

来源: Springer

【 摘 要 】

BackgroundGlioma is the most common malignant brain tumor in adults. The standard treatment scheme of glioma is surgical resection combined alternative radio- and chemotherapy. However, the outcome of glioma patients was unsatisfied. Here, we aimed to explore the molecular and biological function characteristics of GPX7 in glioma.MethodsThe multidimensional data of glioma samples were downloaded from Chinese Glioma Genome Atlas (CGGA). RT-qPCR method was used to identify the expression status of GPX7. Kaplan–Meier curves and Cox regression analysis were used to explore the prognostic value of GPX7. Gene Set Enrichment Analysis (GSEA) was applied to investigate the GPX7-related functions in glioma.ResultsThe results indicated that the expression of GPX7 in glioma was higher compared to that in normal brain tissue. Univariate and multivariate Cox regression analyses confirmed that the expression value of GPX7 was an independent prognostic factor in glioma. The GSEA analysis showed that GPX7 was significantly enriched in the cell cycle pathway, ECM pathway, focal adhesion pathway, and toll-like receptor pathway.ConclusionsThe GPX7 was recommended as an independent risk factor for patients diagnosed with glioma for the first time and GPX7 could be potentially used as the therapy target in future. Furthermore, we attempted to explore a potential biomarker for improving the diagnosis and prognosis of patients with glioma.

【 授权许可】

CC BY