The lung microbiota in Korean patients with non-tuberculous mycobacterial pulmonary disease

BMC Microbiology

Sungwon Jung¹  Hyojung Kim²  Sang Min Lee³  Sang Pyo Lee³  Sung-Yoon Kang³ 

[1] Department of Genome Medicine and Science, Gachon University College of Medicine, Incheon, Republic of Korea;Gachon Institute of Genome Medicine and Science, Gil Medical Center, Gachon University College of Medicine, 38-13 Dokjeom-ro 3 beon-gil, Namdong-gu, 21565, Incheon, Republic of Korea;Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Republic of Korea;Division of Pulmonology and Allergy, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, 21, Namdong-daero 774 beon-gil, Namdong-gu, 21565, Incheon, Republic of Korea;

关键词: Microbiome;    Microbiota;    Nontuberculous mycobacterium;    Nontuberculous mycobacterial pulmonary disease;   

DOI  :  10.1186/s12866-021-02141-1

来源: Springer

【 摘 要 】

BackgroundThe microbiota of the lower respiratory tract in patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD) has not been fully evaluated. We explored the role of the lung microbiota in NTM-PD by analyzing protected specimen brushing (PSB) and bronchial washing samples from patients with NTM-PD obtained using a flexible bronchoscope.ResultsBronchial washing and PSB samples from the NTM-PD group tended to have fewer OTUs and lower Chao1 richness values compared with those from the control group. In both bronchial washing and PSB samples, beta diversity was significantly lower in the NTM-PD group than in the control group (P = 2.25E-6 and P = 4.13E-4, respectively). Principal component analysis showed that the PSBs and bronchial washings exhibited similar patterns within each group but differed between the two groups. The volcano plots indicated differences in several phyla and genera between the two groups.ConclusionsThe lower respiratory tract of patients with NTM-PD has a unique microbiota distribution that is low in richness/diversity.

【 授权许可】

CC BY