Microvascular comparison in younger and older patients with retinal vein occlusion analyzed by OCT angiography

BMC Ophthalmology

Xiaoyun Fang¹  Ke Yao¹  Fang Zheng¹  Tiepei Zhu¹  Panpan Ye¹  Min Zhou² 

[1] Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, No.88, Jiefang Road, 310009, Hangzhou, China;Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, No.88, Jiefang Road, 310009, Hangzhou, China;The Institute of Translational Medicine, Zhejiang University, Hangzhou, China;

关键词: Retinal vein occlusion;    Anti-VEGF treatment;    OCT angiography;    Retinal vasculature;   

DOI  :  10.1186/s12886-021-01931-5

来源: Springer

【 摘 要 】

BackgroundTo compare changes in retinal microvasculature of young and elderly patients with retinal vein occlusion (RVO) after anti-VEGF treatment.MethodsRVO patients who underwent anti-VEGF treatment were retrospectively reviewed and categorized into two groups based on age. The OCT angiography images were obtained during each visit. Best corrected visual acuity (BCVA), vessel density (VD) and foveal avascular zone (FAZ) were measured and compared between the two groups. Vision improvements and retinal microvasculature changes were also correlated.ResultsTwenty patients with 20 eyes were enrolled in the younger group and 46 patients with 46 eyes were enrolled in the older group. Younger patients demonstrated better BCVA, higher VD and smaller FAZ than older patients at 12 months after the first anti-VEGF treatment. The improvement of VD was observed only in the younger group. A positive correlation between vision improvement and VD increase was noted.ConclusionsYoung patients with RVO can achieve rapid rehabilitation of deep retinal vasculature which lead to a better visual outcome.

【 授权许可】

CC BY