期刊论文详细信息
Acta Epileptologica
The role of picornavirus infection in epileptogenesis
Xiaosa Chi1  Jie Mu2  Jing Chi3  Weijia Jiang4  Runxuan Zhang5 
[1] Department of Geriatrics, Affiliated Hospital of Qingdao University, 266000, Qingdao, China;Department of Neurology, West China Hospital of Sichuan University, 610041, Chengdu, China;School of Nursing, The South Medical University, 510515, Guangzhou, China;West China Medical Publishers, West China Hospital of Sichuan University, 610041, Chengdu, China;West China School of Basic Medical Sciences & Fornsic Medicine, Sichuan University, 610041, Chengdu, China;
关键词: Picornaviridae;    Theiler’s murine encephalomyelitis virus;    Seizure;    Immune response;   
DOI  :  10.1186/s42494-021-00040-6
来源: Springer
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【 摘 要 】

Picornaviridae are a family of small positive-strand RNA viruses, and transmitted via the respiratory or fecal-oral route. The neurotropic picornaviruses can induce acute or late recurrent seizures following central nervous system infection, by infecting the peripheral nerve, crossing the blood-brain barrier and migrating in the Trojan-horse method. Theiler’s murine encephalomyelitis virus (TMEV), as a member of Picornaviridae family, can cause encephalitis, leading to chronic spontaneous seizures. TMEV-infected C57BL/6 mice have been used as an animal model for exploring the mechanism of epileptogenesis and assessing new antiepileptic drugs. Astrogliosis, neuronal death and microglial recruitment have been detected in the hippocampus following the picornaviruse-induced encephalitis. The macrophages, monocytes, neutrophils, as well as IL-6 and TNF-α released by them, play an important role in the epileptogenesis. In this review, we summarize the clinical characteristics of picornavirus infection, and the immunopathology involved in the TMEV-induced epilepsy.

【 授权许可】

CC BY   

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