Microbiome analysis reveals gut microbiota alteration of early-weaned Yimeng black goats with the effect of milk replacer and age

Microbial Cell Factories

Zhaoqing Han¹  Taihua Jin¹  Yongzhu Li¹  Shenjin Lv¹  Aoyun Li²  Songkang Qin³  Kun Li⁴  Yan Yang⁵ 

[1] College of Agriculture and Forestry Science, Linyi University, Linyi, China;College of Agriculture and Forestry Science, Linyi University, Linyi, China;College of Veterinary Medicine, Huazhong Agricultural University, 430070, Wuhan, China;College of Veterinary Medicine, Huazhong Agricultural University, 430070, Wuhan, China;Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, 210095, Nanjing, China;Linyi Academy of Agricultural Sciences, 276012, Linyi, China;

关键词: Milk replacer;    Gut microbiota;    Yimeng black goats;    Weaned;    Age;   

DOI  :  10.1186/s12934-021-01568-5

来源: Springer

【 摘 要 】

BackgroundColonization of intestinal microbiota in ruminant during the early life is important to host health, metabolism and immunity. Accumulating evidence revealed the ameliorative effect of milk replacer administration in the gut microbial development of early-weaned ruminants. Yimeng black goats (YBGs) inhabiting Shandong, China show a complex intestinal microbial ecosystem, but studies of their gut microbiota are still insufficient to report. Here, this study was performed to investigate how the gut microbiota develops in weaned YBGs with the effect of age and milk replacer.ResultsResults indicated that both age and milk replacer were important factors to change the gut microbiota of YBGs. Although the alpha diversity of gut microbiota did not change with the age of YBGs, the taxonomic compositions significantly changed. The relative abundance of some beneficial bacteria such as Lachnospiraceae, Ruminococcaceae, Ruminiclostridium, Eubacterium and Barnesiella significantly decreased and subsequently increase with age, which contributes to maintain the stability of intestinal environment and realize the diversity of intestinal functions. The relative abundance of Porphyromonas, Brevundimonas, Flavobacterium, Stenotrophomonas, Propionibacterium, Acinetobacter, Enterococcus and Clostridium belong to pathogenic bacteria in milk replacer-treated YBGs was significantly decreased. Additionally, some beneficial bacteria such as Ruminococcus, Ruminococcaceae, Christensenellaceae and Ruminiclostridium also display a trend of decreasing first followed by gradually increasing.ConclusionsThis study first revealed the gut bacterial community alterations in YBGs with the effect of age and milk replacer. This study also characterized the gut microbial distribution in YBGs with different ages and provided better insight into microbial population structure and diversity of YBGs. Moreover, milk replacer may serve as a good applicant for improving gut microbial development in early-weaned YBGs.

【 授权许可】

CC BY