Differential microRNAs expression profiles in liver from three different lifestyle modification mice models

BMC Genomics

Ming Zhang¹  Ying Zhang²  Huan Gong³  Beidong Chen³  Yiwen Han³  Jing Pang³  Tiemei Zhang³  Wei Wu³  Yanyang Zhao³  Ruomei Qi³ 

[1] Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of China;School of Sport Science, Beijing Sport University, Beijing, People’s Republic of China;The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, 100730, Beijing, People’s Republic of China;

关键词: Caloric restriction;    Exercise;    High-fat diet;    microRNA;    Lifestyle modifications;   

DOI  :  10.1186/s12864-021-07507-3

来源: Springer

【 摘 要 】

BackgroundMicroRNAs play an important role in many fundamental biological and pathological processes. Defining the microRNAs profile underlying the processes by beneficial and detrimental lifestyles, including caloric restriction (CR), exercise and high-fat diet (HF), is necessary for understanding both normal physiology and the pathogenesis of metabolic disease. We used the microarray to detect microRNAs expression in livers from CR, EX and HF mice models. After predicted potential target genes of differentially expressed microRNAs with four algorithms, we applied GO and KEGG to analyze the function of predicted microRNA targets.ResultsWe describe the overall microRNAs expression pattern, and identified 84 differentially expressed microRNAs changed by one or two or even all the three lifestyle modifications. The common and different enriched categories of gene function and main biochemical and signal transduction pathways were presented.ConclusionsWe provided for the first time a comprehensive and thorough comparison of microRNAs expression profiles in liver among these lifestyle modifications. With this knowledge, our findings provide us with an overall vision of microRNAs in the molecular impact of lifestyle on health as well as useful clues for future and thorough research of the role of microRNAs.

【 授权许可】

CC BY