Development and evaluation of two-parameter linear free energy models for the prediction of human skin permeability coefficient of neutral organic chemicals

Journal of Cheminformatics

Sana Naseem¹  Deedar Nabi²  Yasuyuki Zushi³ 

[1] Institute of Environmental Sciences and Engineering (IESE), National University of Sciences and Technology (NUST), H-12, Islamabad, Pakistan;Institute of Environmental Sciences and Engineering (IESE), National University of Sciences and Technology (NUST), H-12, Islamabad, Pakistan;College of Health Sciences, Jumeira University, Dubai, United Arab Emirates;Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology (AIST), 16-1 Onogawa, 305-8569, Tsukuba, Ibaraki, Japan;

关键词: Skin permeability;    Linear Free Energy Relationship (LFER) Modeling;    Abraham solvation model;    GC × GC model;    Complex mixtures;    Dermal Permeability Coefficient Program (DERMWIN™);    QSARs;   

DOI  :  10.1186/s13321-021-00503-5

来源: Springer

【 摘 要 】

The experimental values of skin permeability coefficients, required for dermal exposure assessment, are not readily available for many chemicals. The existing estimation approaches are either less accurate or require many parameters that are not readily available. Furthermore, current estimation methods are not easy to apply to complex environmental mixtures. We present two models to estimate the skin permeability coefficients of neutral organic chemicals. The first model, referred to here as the 2-parameter partitioning model (PPM), exploits a linear free energy relationship (LFER) of skin permeability coefficient with a linear combination of partition coefficients for octanol–water and air–water systems. The second model is based on the retention time information of nonpolar analytes on comprehensive two-dimensional gas chromatography (GC × GC). The PPM successfully explained variability in the skin permeability data (n = 175) with R2 = 0.82 and root mean square error (RMSE) = 0.47 log unit. In comparison, the US-EPA’s model DERMWIN™ exhibited an RMSE of 0.78 log unit. The Zhang model—a 5-parameter LFER equation based on experimental Abraham solute descriptors (ASDs)—performed slightly better with an RMSE value of 0.44 log unit. However, the Zhang model is limited by the scarcity of experimental ASDs. The GC × GC model successfully explained the variance in skin permeability data of nonpolar chemicals (n = 79) with R2 = 0.90 and RMSE = 0.23 log unit. The PPM can easily be implemented in US-EPA’s Estimation Program Interface Suite (EPI Suite™). The GC × GC model can be applied to the complex mixtures of nonpolar chemicals.

【 授权许可】

CC BY