Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia

BMC Urology

K. Y. Wolin¹  R. L. Grubb²  B. N. Breyer³  R. Pakpahan⁴  G. A. Colditz⁴  S. Sutcliffe⁴  G. L. Andriole⁵  Saira Khan⁶  J. Mabie⁷  L. Ragard⁸ 

[1] Coeus Health, 222 W Merchandise Mart Plaza, 60654, Chicago, IL, USA;Department of Urology, Medical University of South Carolina, 135 Rutledge Ave, 29425, Charleston, SC, USA;Departments of Urology and Epidemiology and Biostatistics, University of California - San Francisco, 400 Parnassus Ave # 610, 94143, San Francisco, CA, USA;Division of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of Medicine, Campus Box 8100, 660 S. Euclid Ave., 63110, St. Louis, MO, USA;Division of Urologic Surgery, Department of Surgery, Washington University in St. Louis School of Medicine, 4921 Parkway Place, 63110, St. Louis, MO, USA;Epidemiology Program, College of Health Sciences, University of Delaware, 100 Discovery Blvd., 7th floor, 19713, Newark, DE, USA;Information Management Services, Inc., 1455 Research Blvd, Suite 315, 20850, Rockville, MD, USA;Westat, 1600 Research Blvd, 20850, Rockville, MD, USA;

关键词: Benign Prostatic Hyperplasia (BPH);    Body size;    Obesity;    Nocturia;    Prostate volume;    PLCO;   

DOI  :  10.1186/s12894-021-00816-5

来源: Springer

【 摘 要 】

BackgroundExisting evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related outcomes.MethodsOur study population consisted of men without histories of prostate cancer, BPH-related outcomes, or nocturia in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (n = 4710). Associations for body size in early- (age 20), mid- (age 50) and late-life (age ≥ 55, mean age 60.7 years) and weight change with incident BPH-related outcomes (including self-reported nocturia and physician diagnosis of BPH, digital rectal examination-estimated prostate volume ≥ 30 cc, and prostate-specific antigen [PSA] concentration > 1.4 ng/mL) were examined using Poisson regression with robust variance estimation.ResultsMen who were obese in late-life were 25% more likely to report nocturia (Relative Risk (RR): 1.25, 95% Confidence Interval (CI): 1.11–1.40; p-trendfor continuous BMI < 0.0001) and men who were either overweight or obese in late-life were more likely to report a prostate volume ≥ 30 cc (RRoverweight: 1.13, 95% CI 1.07–1.21; RRobese: 1.10, 95% CI 1.02–1.19; p-trendfor continuous BMI = 0.017) as compared to normal weight men. Obesity at ages 20 and 50 was similarly associated with both nocturia and prostate volume ≥ 30 cc. Considering trajectories of body size, men who were normal weight at age 20 and became overweight or obese by later-life had increased risks of nocturia (RRnormal to overweight: 1.09, 95% CI 0.98–1.22; RRnormal to obese: 1.28, 95% CI 1.10–1.47) and a prostate volume ≥ 30 cc (RRnormal to overweight: 1.12, 95% CI 1.05–1.20). Too few men were obese early in life to examine the independent effect of early-life body size. Later-life body size modified the association between physical activity and nocturia.ConclusionsWe found that later-life body size, independent of early-life body size, was associated with adverse BPH outcomes, suggesting that interventions to reduce body size even late in life can potentially reduce the burden of BPH-related outcomes and nocturia.

【 授权许可】

CC BY