Prevalence of functional gastrointestinal disorders in infants and young children in China

BMC Pediatrics

Marc Alexander Benninga¹  Ying Huang²  Shaman Rajindrajith³  Vanitha Buthmanaban⁴  Panam Parikh⁴  Serene Yaling Tan⁵ 

[1] Academic Medical Center, 1105, Amsterdam, AZ, The Netherlands;Department of Pediatric Gastroenterology, Emma Children’s Hospital, Amsterdam UMC, Academic Medical Center, 1105, Amsterdam, AZ, The Netherlands;Department of Gastroenterology, Children’s Hospital of Fudan University, Shanghai, P.R. China;Department of Pediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka;FrieslandCampina, Amersfoort, The Netherlands;FrieslandCampina, Amersfoort, The Netherlands;FrieslandCampina Development Centre AMEA, 89 Science Park Drive, #02-05/06/08 The Rutherford B, Science Park 1, 118261, Singapore, Singapore;

关键词: Colic;    Regurgitation;    Constipation;    Diarrhea;    Toddler;   

DOI  :  10.1186/s12887-021-02610-6

来源: Springer

【 摘 要 】

BackgroundThe prevalence of functional gastrointestinal disorders (FGIDs) in children, particularly from Asia, is largely unknown. There are not many studies done in Asia especially using the Rome IV criteria. The aim of this study is to assess the prevalence of FGIDs in infants and young children in a representative sample in China.MethodsA prospective, cross-sectional, community-based survey was conducted among healthy infants and young children between the ages of 0–4 years in Jinhua and Shanghai, China. A total of 2604 subjects (1300 subjects from Jinhua and 1304 subjects from Shanghai) completed a validated questionnaire on pediatric gastrointestinal symptoms. FGIDs in infants and young children were diagnosed using the Rome IV criteria.ResultsAccording to the Rome IV criteria, the prevalence of having a FGID in Chinese infants and young children is 27.3%. Infant regurgitation (33.9%) was the most common FGID among the 0–6 months old while functional constipation (7.0%) was the most common among the 1–4 years old. Risk factor analysis revealed that prevalence of infantile colic was higher with better maternal education and low birth weight. Prevalence of infantile regurgitation was significantly greater in males, living in a rural area, being exclusively breast fed at least up to 4 months and starting formula feeds within the first month. The risk of functional constipation was lower for infants who were delivered vaginally.ConclusionsInfantile regurgitation was the most common FGID in Chinese infants while functional constipation was most prevalent among young Chinese children.Trial registrationNetherlands Trial Registry Identifier: NL6973/NTR7161.

【 授权许可】

CC BY