Comparison of the survival outcomes of laparoscopy versus laparotomy in treatment of early-stage ovarian cancer: a systematic review and meta-analysis

Journal of Ovarian Research

Hongyi Wei¹  Jing Zhang¹  Yongjun Wang¹  Qingduo Kong²  Yilin Li² 

[1] Department of Obstetrics and Gynecology, Peking University International Hospital, Life Park of Zhongguancun, Changping District, 102206, Beijing, China;Department of Obstetrics and Gynecology, Peking University International Hospital, Life Park of Zhongguancun, Changping District, 102206, Beijing, China;Clinical Medical College, Weifang Medical University, Weicheng District, 261000, Weifang, Shandong, China;

关键词: Laparoscopy;    Laparotomy;    Ovarian cancer;    Prognosis;    Overall survival;   

DOI  :  10.1186/s13048-021-00793-1

来源: Springer

【 摘 要 】

BackgroundLaparoscopy has been widely used for patients with early-stage epithelial ovarian cancer (eEOC). However, there is limited evidence regarding whether survival outcomes of laparoscopy are equivalent to those of laparotomy among patients with eEOC. The result of survival outcomes of laparoscopy is still controversial. The aim of this meta-analysis is to analyze the survival outcomes of laparoscopy versus laparotomy in the treatment of eEOC.MethodsAccording to the keywords, Pubmed, Embase, Cochrane Library and Clinicaltrials.gov were searched for studies from January 1994 to January 2021. Studies comparing the efficacy and safety of laparoscopy versus laparotomy for patients with eEOC were assessed for eligibility. Only studies including outcomes of overall survival (OS) were enrolled. The meta-analysis was performed using Stata software (Version 12.0) and Review Manager (Version 5.2).ResultsA total of 6 retrospective non-random studies were included in this meta-analysis. The pooled results indicated that there was no difference between two approaches for patients with eEOC in OS (HR = 0.6, P = 0.446), progression-free survival (PFS) (HR = 0.6, P = 0.137) and upstaging rate (OR = 1.18, P = 0.54). But the recurrence rate of laparoscopic surgery was lower than that of laparotomic surgery (OR = 0.48, P = 0.008).ConclusionsLaparoscopy and laparotomy appear to provide comparable overall survival and progression-free survival outcomes for patients with eEOC. Further high-quality studies are needed to enhance this statement.

【 授权许可】

CC BY