Body composition in term offspring after maternal gestational diabetes does not predict postnatal hypoglycemia

BMC Pediatrics

Cornelia Wiechers¹  Lena S. Balles¹  Romy Weber¹  Sara Kirchhof¹  Vanessa Avellina¹  Christian F. Poets¹  Axel R. Franz²  Jan Pauluschke-Fröhlich³  Louise Fritsche⁴  Andreas Fritsche⁵  Hubert Preißl⁵  Manfred Hallschmid⁶ 

[1] Department of Neonatology, University Children’s Hospital, Eberhard Karls University, Calwerstr. 7, 72076, Tuebingen, Germany;Department of Neonatology, University Children’s Hospital, Eberhard Karls University, Calwerstr. 7, 72076, Tuebingen, Germany;Center for Pediatric Clinical Studies, University Children’s Hospital, Eberhard Karls University, Tuebingen, Germany;Department of Obstetrics and Gynecology, University Hospital, Eberhard Karls University, Calwerstraße 7, 72076, Tübingen, Germany;German Center for Diabetes Research, Eberhard Karls University, Tuebingen, Germany;Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University, Tuebingen, Germany;German Center for Diabetes Research, Eberhard Karls University, Tuebingen, Germany;Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University, Tuebingen, Germany;Department of Internal Medicine IV, Eberhard Karls University, Tuebingen, Germany;Institute for Medical Psychology and Behavioural Neurobiology, Eberhard Karls University, Otfried-Müller-Straße 25, 72076, Tübingen, Germany;German Center for Diabetes Research, Eberhard Karls University, Tuebingen, Germany;Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University, Tuebingen, Germany;

关键词: Infant;    Gestational diabetes;    Fetal hyperinsulinemia;    Neonatal;    Body composition;    Air displacement plethysmography;    Fat mass;   

DOI  :  10.1186/s12887-021-02578-3

来源: Springer

【 摘 要 】

BackgroundOffspring of mothers with gestational diabetes mellitus (GDM) have an increased risk of neonatal complications like birth trauma due to macrosomia or postnatal hypoglycemia, as well as long-term metabolic sequelae. Neonatal body composition may be a sensitive marker of metabolic effects on the fetus caused by suboptimal glycemic control during pregnancy.ObjectiveTo determine body composition in offspring of mothers with GDM compared to a reference cohort of healthy term neonates and to assess whether increased body fat would be associated with postnatal hypoglycemia.MethodsThis prospective, observational, cross-sectional study included 311 full-term, singleton infants born between June 2014 and July 2015. Body composition was measured within 96 h of birth using air displacement plethysmography. Results are indicated as median (1st Quartile – 3rd Quartile).ResultsOf 311 infants, 40 (12.9%) were born to mothers with GDM. Birth weight standard deviation scores (SDS) (0.24 vs. − 0.07, p = 0.04), fat mass (370 g vs. 333 g, p = 0.02) as well as fat mass/total body mass (BF%; 11.4% vs. 10.8%, p = 0.03) were significantly higher in infants following maternal GDM than in controls. In GDM offspring, anthropometric parameters, fat mass or BF% did not differ between infants with or without postnatal hypoglycemia. In this cohort, SDS for birth weight, fat mass, fat free mass, BF% or postnatal hypoglycemia were not associated with maternal blood glucose levels measured at an oral glucose tolerance test.ConclusionsSDS for birth weight, neonatal fat mass, and BF% were significantly higher in newborns following maternal GDM. In these infants born to mothers with GDM, body composition did not differ between those with or without postnatal hypoglycemia.

【 授权许可】

CC BY