Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis

Natural Products and Bioprospecting

Yu Zhang¹  Qian Zhao¹  Wen-Tao Zhu¹  Zong-Qing Huo¹  Xiao-Jiang Hao¹ 

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, PR China;

关键词: Bousigonia;    B. angustifolia;    B. mekongensis;    Monoterpenoid indole alkaloids;    Bousmekines A-E;   

DOI  :  10.1007/s13659-020-00278-6

来源: Springer

【 摘 要 】

Four new monoterpenoid indole alkaloids, bousmekines A-D (1–4), and one new pyranopyridine alkaloid, bousmekine E (5), were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis. Their structures including absolute configurations were elucidated by a combination of MS, NMR, ECD calculation, and single-crystal X-ray diffraction analysis. Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety. Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC50 values of 0.8–7.4 μM.Graphic Abstract

【 授权许可】

CC BY