Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA

EJNMMI Radiopharmacy and Chemistry

Mariette M. Pereira¹  Inês Fonseca²  Ivanna Hrynchak²  Ângela C. B. Neves²  Antero J. Abrunhosa²  Vítor H. P. Alves²  Amílcar Falcão³ 

[1] Coimbra Chemistry Center, Chemistry Department, University of Coimbra, Rua Larga, 3004-535, Coimbra, Portugal;ICNAS/CIBIT — Institute for Nuclear Sciences Applied to Health, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal;ICNAS/CIBIT — Institute for Nuclear Sciences Applied to Health, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal;Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal;

关键词: 6-[18F]FDOPA;    Automated synthesis;    PET;    Radiochemistry;    Nonproteinogenic amino acid;   

DOI  :  10.1186/s41181-021-00126-z

来源: Springer

【 摘 要 】

The neurotracer 6-[18F] FDOPA has been, for many years, a powerful tool in PET imaging of neuropsychiatric diseases, movement disorders and brain malignancies. More recently, it also demonstrated good results in the diagnosis of other malignancies such as neuroendocrine tumours, pheochromocytoma or pancreatic adenocarcinoma.The multiple clinical applications of this tracer fostered a very strong interest in the development of new and improved methods for its radiosynthesis. The no-carrier-added nucleophilic 18F-fluorination process has gained increasing attention, in recent years, due to the high molar activities obtained, when compared with the other methods although the radiochemical yield remains low (17–30%). This led to the development of several nucleophilic synthetic processes in order to obtain the product with molar activity, radiochemical yield and enantiomeric purity suitable for human PET studies.Automation of the synthetic processes is crucial for routine clinical use and compliance with GMP requirements. Nevertheless, the complexity of the synthesis makes the production challenging, increasing the chance of failure in routine production. Thus, for large-scale clinical application and wider use of this radiopharmaceutical, progress in the automation of this complex radiosynthesis is of critical importance.This review summarizes the most recent developments of 6-[18F]FDOPA radiosynthesis and discusses the key issues regarding its automation for routine clinical use.

【 授权许可】

CC BY