Different dosage regimens of Eptinezumab for the treatment of migraine: a meta-analysis from randomized controlled trials

The Journal of Headache and Pain

Shujun Chen¹  Tao Xue²  Xin Wu²  Zeya Yan²  Guangjie Liu²  Zhouqing Chen²  Xingyu Yang²  Zhong Wang²  Shan Gao³ 

[1] Department of Neurology, The First Affiliated Hospital of Soochow University, 215006, Suzhou, Jiangsu Province, China;Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, 215006, Suzhou, Jiangsu Province, China;Department of Neurosurgery, The People’s Hospital of SND, 215129, Suzhou, Jiangsu Province, China;

关键词: Eptinezumab;    Migraine;    Dosage regimen;    Meta-analysis;   

DOI  :  10.1186/s10194-021-01220-y

来源: Springer

【 摘 要 】

BackgroundMigraine is one of the most common neurological diseases around the world and calcitonin gene-related peptide (CGRP) plays an important role in its pathophysiology. Therefore, in the present study, we evaluated the efficacy of monoclonal antibodies blocking the CGRP ligand or receptor in episodic and chronic migraine.ObjectiveThe objective of our study is implementing a meta-analysis to systematically evaluate the efficacy and safety of eptinezumab for the treatment of migraine compared with placebo.MethodWe searched the Medline, Embase, Cochrane Library and Clinicaltrials.gov for randomized controlled trials (RCTs) which were performed to evaluate eptinezumab versus placebo for migraine up to September 2020. The data was assessed by Review Manager 5.3 software. The risk ratio (RR) and standard mean difference (SMD) were analyzed using dichotomous outcomes and continuous outcomes respectively with a random effect model.ResultWe collected 2739 patients from 4 RCTs: the primary endpoint of efficacy was the change from baseline to week 12 in mean monthly migraine days (MMDs). We found that eptinezumab (30 mg, 100 mg, 300 mg) led to a significant reduction in MMDs (P = 0.0001,P < 0.00001, P < 0.00001) during 12 weeks compared with placebo, especially with 300 mg. For the safety, we compared and concluded the treatment emergent adverse events (TEAEs) of the 4 RCTs. This indicated no evident statistical difference between eptinezumab and placebo.ConclusionsIn the present study, we found that eptinezumab is safe and has significant efficacy in the treatment of migraine, especially the dose of 300 mg.

【 授权许可】

CC BY