Diversity roles of CHD1L in normal cell function and tumorigenesis

Biomarker Research

Ningfang Ma¹  Xudong Lai²  Xifeng Xiong³  Aiguo Li³  Zhihe Liu³ 

[1] Affiliated Cancer Hospital and Institute of Guangzhou Medical University, 510095, Guangzhou, China;Department of Histology and Embryology, Guangzhou Medical University, Xinzao Town, Panyu District, 511436, Guangzhou, China;Departement of infectious disease, Guangzhou Red Cross Hospital, Jinan University, 510220, Guangzhou, China;Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Jinan University, 510220, Guangzhou, China;

关键词: CHD1L;    ALC1;    SNF2;    Chromatin remodeling;    Tumorigenesis;   

DOI  :  10.1186/s40364-021-00269-w

来源: Springer

【 摘 要 】

Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a multifunctional protein participated in diverse cellular processes, including chromosome remodeling, cell differentiation and development. CHD1L is a regulator of chromosomal integrity maintenance, DNA repair and transcriptional regulation through its bindings to DNA. By regulating kinds of complex networks, CHD1L has been identified as a potent anti-apoptotic and pro-proliferative factor. CHD1L is also an oncoprotein since its overexpression leads to dysregulation of related downstream targets in various cancers. The latest advances in the functional molecular basis of CHD1L in normal cells will be described in this review. As the same time, we will describe the current understanding of CHD1L in terms of structure, characteristics, function and the molecular mechanisms underlying CHD1L in tumorigenesis. We inference that the role of CHD1L which involve in multiple cellular processes and oncogenesis is well worth further studying in basic biology and clinical relevance.

【 授权许可】

CC BY