When MARCH family proteins meet viral infections

Virology Journal

Chunfu Zheng¹  Yan-Dong Tang² 

[1] Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China;Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada;State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China;

关键词: MARCH;    Antiviral;    Proviral;    RING finger;    E3 ligase;   

DOI  :  10.1186/s12985-021-01520-4

来源: Springer

【 摘 要 】

Membrane-associated RING-CH (MARCH) ubiquitin ligases belong to a RING finger domain E3 ligases family. Recent studies have demonstrated that MARCH proteins play critical roles during various viral infections. MARCH proteins can directly antagonize different steps of the viral life cycle and promote individual viral infection. This mini-review will focus on the latest advances of MARCH family proteins' emerging roles during viral infections.

【 授权许可】

CC BY