Porphyrin Iron-Grafted Mesoporous Silica Composites for Drug Delivery, Dye Degradation and Colorimetric Detection of Hydrogen Peroxide

Nanoscale Research Letters

Ling Cai¹  Ping Zhu¹  Jin Chen²  Zhihui Xu³ 

[1] Center for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, Jiangsu, China;Center for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, Jiangsu, China;The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, 211166, Nanjing, Jiangsu, China;Jiangsu Province Engineering Research Center of Antibody Drug, Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University, 211166, Nanjing, China;Suzhou Center for Disease Prevention and Control, 215000, Suzhou, Jiangsu, China;The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, 211166, Nanjing, Jiangsu, China;

关键词: Mesoporous silica;    Interfaces;    Composite materials;    Hemin;    Drug delivery;    Real-time cell analysis;   

DOI  :  10.1186/s11671-021-03501-6

来源: Springer

【 摘 要 】

Porphyrin iron molecules (hemin) were successfully grafted on the channeled mesoporous silica of SBA-15 (FeIX-SBA-15), in which attached hemin molecules acted as the enzyme mimic for catalyzing oxidation reactions. In the presence of H2O2, the prepared FeIX-SBA-15 composite effectively degraded industrial dye Orange II and catalyzed tetramethylbenzidine hydrochloride (TMB) both in the solution and on the membrane, from which the colorimetric H2O2 detection was achieved. Moreover, the hemin-grafted composites showed high loading content of anticancer drug of doxorubicin hydrochloride (DOX) displaying the sustained releasing behavior as monitored by real-time cell analysis, which resulted in improved inhibitory effect on cancer cells growth compared with that DOX/SBA-15. The hemin-modified mesoporous silica nanocomposite provides an integrated nanoplatform with promising biomedical applications.

【 授权许可】

CC BY