Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications

The Journal of Headache and Pain

Giorgia Sforza¹  Anna Tobia²  Carmela Loiacono³  Raffaele Ornello⁴  Triinu Niiberg-Pikksööt⁵  Kaat Guldolf⁶  Gianluca Serafini⁷  Thomas Dresler⁸  Marta Puma⁹  Salvatore Caratozzolo^1,10  Jana-Isabel Huhn^1,11 

[1]Child Neurology Unit, Department of Neuroscience and Neurorehabilitation, Headache Center, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

[2]Child Neuropsychiatry Unit, ASL 3, Turin, Italy

[3]Child Neuropsychiatry school, University of Palermo, Palermo, Italy

[4]Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila, L’Aquila, Italy

[5]Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia

[6]Department of Neurology, University Hospital Brussels, Jette, Belgium

[7]Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, Genoa, Italy

[8]IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy

[9]Department of Psychiatry & Psychotherapy, University Hospital Tuebingen, Tuebingen, Germany

[10]LEAD Graduate School & Research Network, University of Tuebingen, Tuebingen, Germany

[11]Headache Centre & Neurocritical Care Unit, Department of Human Neurosciences, Sapienza - University of Rome, Viale dell’Università 30, 00185, Rome, Italy

[12]Neurology Unit - Neurological and Vision Sciences Department, ASST Spedali Civili of Brescia, Brescia, Italy

[13]Praxis Gendolla, Specialized care for Psychiatry, Neurology, Psychotherapy and Pain Therapy, Essen, Germany

关键词: Migraine;    Psychiatric disorders;    Comorbidity;    Biological pathways;   

DOI  :  10.1186/s10194-019-0988-x

来源: Springer

【 摘 要 】

BackgroundMigraine is a highly prevalent and disabling neurological disorder which is commonly linked with a broad range of psychiatric comorbidities, especially among subjects with migraine with aura or chronic migraine. Defining the exact nature of the association between migraine and psychiatric disorders and bringing out the pathophysiological mechanisms underlying the comorbidity with psychiatric conditions are relevant issues in the clinical practice.MethodsA systematic review of the most relevant studies about migraine and psychiatric comorbidity was performed using “PubMed”, “Scopus”, and “ScienceDirect” electronic databases from 1 January 1998 to 15 July 2018. Overall, 178 studies met our inclusion criteria and were included in the current review.ResultsAccording to the most relevant findings of our overview, the associations with psychiatric comorbidities are complex, with a bidirectional association of major depression and panic disorder with migraine. Importantly, optimizing the pharmacological and non-pharmacological treatment of either migraine or its psychiatric comorbidities might help clinicians to attenuate the burden of both these conditions.ConclusionsThe available data highlight the need for a comprehensive evaluation of psychiatric disorders in migraine in order to promote an integrated model of care and carefully address the burden and psychosocial impairment related to psychiatric comorbidities in migraine.

【 授权许可】

CC BY