HMGB1 coordinates SASP‐related chromatin folding and RNA homeostasis on the path to senescence

Molecular Systems Biology

Yulia Kargapolova¹  Milos Nikolic¹  Anne Zirkel¹  Theodore Georgomanolis²  Janine Altmüller³  Christian Becker³  Vassiliki Varamogianni‐Mamatsi⁴  Athanasia Mizi⁴  Eduardo G Gusmao⁴  Konstantinos Sofiadis⁴  Nadine Übelmesser⁴  Ioanna Papadionysiou⁴  Natasa Josipovic⁴  Argyris Papantonis⁵  Gary Loughran⁶  Audrey Michel⁶  James Keane⁷ 

[1] Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany;Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany;Cologne Center for Genomics, University of Cologne, Cologne, Germany;Cologne Center for Genomics, University of Cologne, Cologne, Germany;Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany;Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany;Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany;Ribomaps, Cork, Ireland;Ribomaps, Cork, Ireland;Cork Institute of Technology, Cork, Ireland;

关键词: 3D chromatin folding;    loop;    replicative senescence;    RNA splicing;    senescence‐associated secretory phenotype;   

DOI  :  10.15252/msb.20209760

来源: Wiley

【 授权许可】

CC BY