The effect of insulin-like growth factor 1 on the recovery of facial nerve function in a guinea pig model of facial palsy

The journal of physiological sciences

article

Motoyasu Sugiyama¹  Tsukasa Ito¹  Takatoshi Furukawa¹  Atsushi Hirayama²  Seiji Kakehata¹ 

[1] Department of Otolaryngology, Yamagata University Faculty of Medicine;Public Health, Department of Social Medicine, Graduate School of Medicine, Osaka University

关键词: Peripheral facial nerve palsy;    Insulin-like growth factor 1;    Electroneurography;    Physiological function;    Gelatin-based hydrogel;   

DOI  :  10.1186/s12576-020-00755-0

来源: Springer

【 摘 要 】

The efficacy of insulin-like growth factor 1 (IGF-1) in the treatment of peripheral facial nerve palsy was investigated using an animal model. The facial nerve within the temporal bone was exposed and compressed by clamping. The animals were treated with either IGF-1 or saline which was topically administered by a gelatin-based sustained-release hydrogel via an intratemporal route. The recovery from facial nerve palsy was evaluated at 8 weeks postoperatively based on eyelid closure, complete recovery rate, electroneurography and number of axons found on the facial nerve. IGF-1 treatment resulted in significant improvement in the changes of the degree of eyelid closure over the total time period and complete recovery rate. A separate study showed that IGF-1 receptor mRNA was expressed in facial nerves up to 14 days after the nerve-clamping procedure. IGF-1 was thus found to be effective in the treatment of peripheral facial nerve palsy when topically applied using a sustained-release gelatin-based hydrogel via an intratemporal route.

【 授权许可】

Unknown