Acupuncture attenuates the development of diabetic peripheral neuralgia by regulating P2X4 expression and inflammation in rat spinal microglia

The journal of physiological sciences

article

He-yong Tang¹  Fan-jing Wang²  Jun-long Ma²  Hao Wang²  Guo-ming Shen¹  Ai-juan Jiang² 

[1] Graduate School of Anhui, Anhui University of Chinese Medicine;School of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine;Anhui Province Key Laboratory of Research & Development of Chinese Medicine

关键词: Acupuncture;    Diabetic peripheral neuralgia;    P2X4;    Diabetic rat;   

DOI  :  10.1186/s12576-020-00769-8

来源: Springer

【 摘 要 】

Diabetic peripheral neuropathy (DPN) is a chronic microvascular complication of diabetes. The purpose of this study is to find the underlying mechanism for the effects of acupuncture in DPN rats. Rats were rendered diabetic with a single injection of 35 mg/kg streptozotocin (STZ). These STZ-diabetic rats were treated with acupuncture for 20 min once daily. The therapeutic efficacy of acupuncture was assessed using mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) evaluations. After 14 days treatment, acupuncture markedly reduced the pathological injury in STZ-diabetic rats. Moreover, it significantly down-regulated P2X4 and OX42 expression along with the reduced levels of inflammatory factors (CXCR3, TNF-α, IL-1β, IL-6), GSP and lipid metabolisms in the spinal cord of the DPN rats. Acupuncture could relieve DPN in rats by regulating P2X4 expression and inflammation in spinal microglia.

【 授权许可】

Unknown