Two-year outcome comparison of decompression in 14 lipomatosis cases with 169 degenerative lumbar spinal stenosis cases: a Swiss prospective multicenter cohort study

European spine journal

article

Nils H. Ulrich¹  Isaac Gravestock¹  Sebastian Winklhofer³  Iliya Peyneshki³  Maria M. Wertli¹  Giuseppe Pichierri¹  Tamás F. Fekete⁶  François Porchet⁶  Mazda Farshad²  Johann Steurer¹  Jakob M. Burgstaller¹ 

[1] Horten Centre for Patient Oriented Research and Knowledge Transfer, University of Zurich;University Spine Centre Zurich, Balgrist University Hospital, University of Zurich;Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich;Division of General Internal Medicine, Bern University Hospital, Bern University;Institute for Primary Care, University and University Hospital Zurich;Department of Orthopedics and Neurosurgery, Spine Center, Schulthess Clinic

关键词: Spinal epidural lipomatosis;    Stenosis;    Surgical decompression;    Lumbar spine;    Lipomatosis;   

DOI  :  10.1007/s00586-020-06449-w

来源: Springer

【 摘 要 】

Spinal epidural lipomatosis (SEL) is defined as an abnormal and extensive accumulation of unencapsulated adipose tissue within the spinal epidural space. To date, there is a lack of high-level evidence studies reporting the outcome of surgical treatment of symptomatic SEL in patients with lumbar spinal stenosis (LSS). The aim was to compare clinical outcomes in patients with symptomatic LSS with and without SEL who underwent decompression surgery alone at the 12- and 24-month follow-up. One hundred and eighty-three patients met the inclusion criteria, of which 14 had mainly SEL on at least one level operated in addition to possible degenerative changes on other levels and 169 degenerative LSS only. The main outcomes were pain (Spinal Stenosis Measure (SSM) symptoms), disability (SSM function), and quality of life [EQ-5D-3L summary index (SI)] at 24-month follow-up, and minimal clinically important difference (MCID) in SSM symptoms, SSM function, and EQ-5D-3L SI. The multiple regression linear models showed that SEL was associated with worse SSM symptoms (p = 0.045) and EQ-5D-3L SI scores (p = 0.026) at 24-month follow-up, but not with worse SSM function scores. Further, depression (in all models) was negatively associated with better clinical outcomes at 24-month follow-up. In the outcomes SSM symptoms and EQ-5D-3L SI, distinctly more patients in the classical LSS group reached MCID than in the SEL group (71.3% and 62.3% vs. 50.0% and 42.9%). Our study demonstrated that decompression alone surgery was associated with significant improvement in disability in both groups at 2 years, but not in pain and quality of life in patients with SEL.

【 授权许可】

Unknown