Percutaneous albumin/doxycycline injection versus open surgery for aneurysmal bone cysts in the mobile spine

European spine journal

article

Xiao Liu¹  Song Bo Han²  Gao Si¹  Shao Ming Yang⁴  Chang Ming Wang⁵  Liang Jiang¹  Feng Wei¹  Feng Liang Wu¹  Xiao Guang Liu¹  Zhong Jun Liu¹ 

[1] Department of Orthopaedics, Peking University Third Hospital;Department of Radiology, Peking University Third Hospital;Peking University Health Science Center;Department of Pathology, Peking University Health Science Center;Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital

关键词: Spinal tumor;    Aneurysmal bone cyst;    Percutaneous doxycycline treatment;    Open surgery;    Recurrence;   

DOI  :  10.1007/s00586-018-5836-1

来源: Springer

【 摘 要 】

This study aimed to validate the safety and effectiveness of percutaneous doxycycline/albumin injection for spinal aneurysmal bone cysts (ABCs) as an alternative to open surgery. From January 2000 to December 2016, 25 patients who had no/minor neurological deficits (modified Frankel scale D or E) and acceptable local stability (spinal instability neoplastic score < 12) were included in the study, of whom 14 were treated with percutaneous doxycycline/albumin injection (injection group) and 11 were treated with open surgery (surgery group). The demographic and clinical information of the injection and surgery groups were recorded and compared. In the injection group, lesion size was significantly reduced in all 14 patients, all patients showed complete neurological recovery, and 13 patients had complete relief of neck pain; their mean visual analogue scale (VAS) decreased from 3.4 to 0.5. No complication or recurrence was observed during the mean 30.7-month follow-up (range, 24–50 months). In the surgery group, 9 patients had complete neurological recovery and 2 patients had residual slight paresthesia; their mean VAS decreased from 3.4 to 0.5. Two had local recurrence during their follow-up at 66.5 months (range, 50–96 months). Compared with the surgery group, the injection group showed no significant difference in the rate of recurrence (P = 0.14) and complication (P = 0.36). Percutaneous doxycycline/albumin injection for spinal ABCs can be safely and effectively performed in well-selected cases. It could serve as an alternative treatment, especially for spinal ABCs lesions with acceptable local stability and in patients without severe neurological deficits. These slides can be retrieved under Electronic Supplementary Material.

【 授权许可】

Unknown