A Study on Impact of BPA in the Adipose Tissue Dysfunction (Adiposopathy) in Asian Indian Type 2 Diabetes Mellitus Subjects

Indian journal of clinical biochemistry

article

Jyoti Jain¹  Nidhi Gupta²  Rati Mathur¹  Surendra Nimesh³  Sandeep K. Mathur⁴ 

[1] Department of Biochemistry, SMS Medical College and Hospital;Research and Development Cell, Department of Biotechnology, IIS (Deemed to be University);Department of Biotechnology, School of Life Sciences, Central University of Rajasthan;Department of Endocrinology, SMS Medical College and Hospital

关键词: Bisphenol-A Adiposopathy Type 2 diabetes mellitus Endocrine disruptors Adipose tissues;   

DOI  :  10.1007/s12291-019-00843-y

来源: Springer

【 摘 要 】

A surge to increase the production via usage of chemicals at both industrial and agricultural arena has forced humans to be routinely and imprudently exposed to a wide variety of endocrine disrupting chemicals. The overall aim of the study was to evaluate possible relation that might exist between bisphenol-A (BPA) and the adipose tissue hormones, and further impact on adiposopathy. In the present study, the role of BPA, an “endocrine disruptor” with respect to adiposopathy was evaluated in type 2 diabetes mellitus patients. For the study, 150 healthy control subjects and 150 newly diagnosed diabetes patients were recruited. Fasting venous blood samples was analyzed for several biochemical parameters such as serum glucose, lipid profile, insulin, adiponectin, leptin, TNF-α, IL-6, IL-1, free fatty acid. Concentrations of BPA were also measured both in control and diabetic subjects. Serum BPA concentration was found to be significantly higher in diabetic subjects in comparison to the control subjects. Levels of BPA were found to be positively correlated with BMI and WC in diabetic subjects. Also, it was found to be positively correlated with leptin and negatively correlated with adiponectin in diabetic subjects. Therefore, the current study suggested more deleterious effect of BPA on diabetes and its pathophysiology.

【 授权许可】

Unknown