Association Between Serum Testosterone and Serum PSA Among Men With and Without Partial Androgen Deficiency

Indian journal of clinical biochemistry

article

A. Shukla¹  B. Sharda²  S. Sharma³  S. Bhardwaj¹  U. Kailash⁴  R. Kalani¹  L. Satyanarayana⁴  A. Shrivastava⁴ 

[1]Department of Biochemistry, Rajiv Gandhi Super Specialty Hospital

[2]Department of Urology, RG Stone Urology and Laparoscopy Hospital

[3]Department of Biochemistry, All India Institute of Medical Sciences

[4]ICMR-National Institute of Cancer Prevention and Research

关键词: Testosterone PSA PADAM Aging males Introduction Prostate-specific antigen (PSA) is a serine protease;    which is produced by prostatic epithelium [1];    PSA;    PSA velocity;    PSA density and free PSA have long been used as indicators to decide for prostate biopsy in prostate cancer diagnosis;    Though;    PSA does not come under the category Testosterone PSA PADAM Aging males;   

DOI  :  10.1007/s12291-018-0785-3

来源: Springer

【 摘 要 】

Serum prostatic specific antigen (PSA) and serum testosterone levels share an undefined relationship with each other, with many conflicting studies showing both positive and negative correlation between them. Our aim was to assess association between serum PSA and serum testosterone in healthy men with normal testosterone levels and men with partial androgen deficiency (PADAM). A cross sectional study was conducted at a teaching hospital setting where serum testosterone and aging male symptom scale (AMS) scores along with PSA were studied in 255 men (> 50 years) with and without PADAM. Mean total testosterone and serum PSA was 9.35 ± 1.33 nmol/L, 1.96 ± 0.76 ng/mL in males with PADAM and 15.30 ± 1.95 nmol/L, 1.85 ± 0.73 ng/mL respectively in males without PADAM. No significant relationship was observed between serum PSA and serum testosterone levels among healthy males irrespective of PADAM in the study population. We suggest, there is no need to adjust PSA values for biopsy decisions according to testosterone levels.

【 授权许可】

Unknown