Effect of Gender, Age, Diet and Smoking Status on the Circadian Rhythm of Serum Uric Acid of Healthy Indians of Different Age Groups

Indian journal of clinical biochemistry

article

Ranjana Singh¹  Pramod Kumar²  Devendra Nath Mishra³  Ashok Kumar Singh³  Raj Kumar Singh³  Abbas Ali Mahdi⁴  Cathy Lee Gierke⁵  Germaine Cornelissen⁵ 

[1] Biochemistry Department, King George’s Medical University;Medicine Department, T S Misra Medical College and Hospital;Biochemistry Department, T S Misra Medical College and Hospital;Era University;Halberg Chronobiology Center, University of Minnesota

关键词: Circadian rhythm Age Diet Gender Smoking Uric acid Epidemiology Healthy population;   

DOI  :  10.1007/s12291-017-0724-8

来源: Springer

【 摘 要 】

The circadian rhythm of uric acid concentration was studied under near-normal tropical conditions in 162 healthy volunteers (103 males and 59 females; 7 to 75 year). They were mostly medical students, staff members and members of their families. They were classified into 4 age groups: A (7–20 y; N = 42), B (21–40 y; N = 60), C (41–60 y; N = 35) and D (61–75 y; N = 25). They followed a diurnal activity from about 06:00 to about 22:00 and nocturnal rest. Blood samples were collected from each subject every 6 for 24 h (4 samples). Serum uric acid was measured spectrophotometrically. Data from each subject were analyzed by cosinor rhythmometry. Effects of gender, age, diet (vegetarian vs. omnivore), and smoking status on the rhythm-adjusted mean (MESOR) and circadian amplitude were examined by multiple-analysis of variance. A marked circadian variation was found in uric acid concentration in healthy Indians of all age groups. Furthermore, both the MESOR and circadian amplitude underwent changes with advancing age. In addition to effects of gender and age, diet and smoking were also found to affect the MESOR of circulating uric acid concentration in healthy Indians residing in northern India. The present observations confirmed a definite rhythm in uric acid concentrations with significant effect of gender, age, diet, and smoking status on uric acid concentration in clinical health. Mapping the circadian rhythm of serum uric acid is needed to explore their role in different pathophysiological conditions.

【 授权许可】

Unknown