The Differential Influence of Immunological Process of Autoimmune Disease on Lipid Metabolism: A Study on RA and SLE

Indian journal of clinical biochemistry

article

S. Chandrashekara¹  Sachin Vithalrao Dhote¹  K. R. Anupama¹ 

[1] ChanRe Rheumatology and Immunology Center and Research

关键词: Atherogenic index Autoimmune diseases Immunopathologic process Inflammatory process Lipid metabolism Serum uric acid;   

DOI  :  10.1007/s12291-017-0715-9

来源: Springer

【 摘 要 】

Metabolic parameters like uric acid, lipids and homocysteine are influenced by immunopathological mechanisms underlying the autoimmune disease processes. The current study examined the differences in these parameters and the correlation between inflammatory and metabolic variables in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients. The cross-sectional prospective study included 24 treatment-naïve patients with moderate to severe diseases-15 subjects had RA and 9 had SLE. Atherogenic index of plasma (AIP) was used to assess the cardiovascular risk of the patients. Spearman’s correlation was performed to verify the relationship between inflammatory and metabolic parameters. A two-tailed P  0.24 AIP score) and RA patients in comparison had lower risk. Correlation among serum uric acid, lipid profile constituents and AIP was noted. The immunological process of SLE has greater impact on the metabolic parameters. Higher uric acid levels are suggestive of dysfunctional lipid profile. Understanding the implications of risk factors and its inflammatory role in autoimmune processes may assist in disease management.

【 授权许可】

Unknown