Anomalies in MiRNAs Machinery Gene, GEMIN-4 Variants Suggest Renal Cell Carcinoma Risk: A Small Experimental Study from North India

Indian journal of clinical biochemistry

article

Archana Verma¹  Vibha Singh¹  Praveen Kumar Jaiswal¹  Rama D. Mittal¹ 

[1] Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences

关键词: Renal cell carcinoma (RCC) GEMIN4 gene Cancer susceptibility;   

DOI  :  10.1007/s12291-017-0722-x

来源: Springer

【 摘 要 】

GEMIN4 is a member of the GEMIN gene family which is involved in multiple pathologies including cancer. It is located on Chr17p13.3, the most notorious chromosome and a hotspot for various carcinomas. We therefore intend to find genetic variants of GEMIN4 gene associated with renal cell carcinoma risk (RCC). This study comprised 100 patients and 225 controls. Genotyping of GEMIN4 gene variants was done using Taqman® assay. The association of GEMIN4 variants and risk prediction of RCC was done by statistical analysis. Haplotype analysis was done to see the combined effect of variants on RCC. Patients carrying variant genotype, CC of GEMIN4 T/C rs7813 showed significant association whereas in case of GEMIN4 G/C rs910925 variant genotype, CC significant risk was found. GEMIN4 rs7813 T/C variant genotype, CC showed risk with smoking (p = 0.034). Our study gives a substantive support for the association between the GEMIN4 gene variants and RCC risk.

【 授权许可】

Unknown