Involvement of P2 receptors in hematopoiesis and hematopoietic disorders, and as pharmacological targets

Purinergic signalling

article

Kelly Juliana Filippin¹  Kamylla F. S. de Souza²  Roberto Theodoro de Araujo Júnior²  Heron Fernandes Vieira Torquato²  Dhébora Albuquerque Dias¹  Eduardo Benedetti Parisotto¹  Alice Teixeira Ferreira²  Edgar J. Paredes-Gamero¹ 

[1] Faculdade de Ciências Farmacêuticas, Universidade Federal de Mato Grosso do Sul;Universidade Federal de São Paulo;Universidade Braz Cubas;Faculdade de Ciências Farmacêuticas, Laboratório de Biologia Molecular e Culturas Celulares

关键词: P2 receptor;    Hematopoiesis;    Hematopoietic stem cell;    Leukemia;    Platelets;    Pharmacological target;   

DOI  :  10.1007/s11302-019-09684-z

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Several reports have shown the presence of P2 receptors in hematopoietic stem cells (HSCs). These receptors are activated by extracellular nucleotides released from different sources. In the hematopoietic niche, the release of purines and pyrimidines in the milieu by lytic and nonlytic mechanisms has been described. The expression of P2 receptors from HSCs until maturity is still intriguing scientists. Several reports have shown the participation of P2 receptors in events associated with modulation of the immune system, but their participation in other physiological processes is under investigation. The presence of P2 receptors in HSCs and their ability to modulate this population have awakened interest in exploring the involvement of P2 receptors in hematopoiesis and their participation in hematopoietic disorders. Among the P2 receptors, the receptor P2X7 is of particular interest, because of its different roles in hematopoietic cells (e.g., infection, inflammation, cell death and survival, leukemias and lymphomas), making the P2X7 receptor a promising pharmacological target. Additionally, the role of P2Y12 receptor in platelet activation has been well-documented and is the main example of the importance of the pharmacological modulation of P2 receptor activity. In this review, we focus on the role of P2 receptors in the hematopoietic system, addressing these receptors as potential pharmacological targets.

【 授权许可】

CC BY