Inhibition of the adenosinergic pathway: the indispensable part of oncological therapy in the future

Purinergic signalling

article

Yi Huang¹  Zili Gu¹  Yang Fan¹  Guangxi Zhai¹  Xiaogang Zhao²  Qifeng Sun²  Yanbin Shi³  Guimei Lin¹ 

[1] School of Pharmaceutical Science, Shandong University;Department of Thoracic Surgery, Second Hospital of Shandong University;School of Mechanical & Automotive Engineering, Qilu University of Technology (Shandong Academy of Sciences)

关键词: Immunosuppression;    Poor prognosis;    Adenosine;    Targeted nanoparticles;   

DOI  :  10.1007/s11302-018-9641-4

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

In recent years, immunotherapy has produced many unexpected breakthroughs in oncological therapy; however, it still has many deficiencies. For example, the number of patients who are unresponsive to anti-programmed death-ligand 1 (PD-L1), anti-cytotoxic T-like antigen-4 (CTLA4), and anti-programmed death-1 (PD1) therapies cannot be ignored, and the search for an undiscovered immunosuppressive pathway is imminent. Five decades ago, researchers found that activation of the adenosinergic pathway was negatively correlated with prognosis in many cancers. This review describes the entire process of the adenosinergic pathway in the tumor microenvironment and the mechanism of immunosuppression, which promotes tumor metastasis and drug resistance. Additionally, the review explores factors that regulate this pathway, including signaling factors secreted by the tumor microenvironment and certain anti-tumor drugs. Additionally, the combination of adenosinergic pathway inhibitors with chemotherapy, checkpoint blockade therapy, and immune cell-based therapy is summarized. Finally, certain issues regarding treatment via inhibition of this pathway and the use of targeted nanoparticles to reduce adverse reactions in patients are put forward in this review.

【 授权许可】

CC BY