On-chip cell manipulation and applications to deformability measurements

ROBOMECH Journal

article

Hiroaki Ito¹  Makoto Kaneko² 

[1] Department of Physics, Graduate School of Science, Chiba University;Division of Mechanical Engineering, Graduate School of Science and Technology, Meijo University

关键词: Lab-on-a-chip;    Microfluidics;    Cell mechanics;    Deformability;    On-chip manipulation;    Diagnosis;   

DOI  :  10.1186/s40648-020-0154-x

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

Active microfluidics for the applications to cellular deformability measurements is an emerging research field ranging from engineering to medicine. Here, we review conventional and microfluidic methods, and introduce an on-chip cell manipulation system with the design principle of fast and fine cell manipulation inside a microchannel. In the latter part of the review, we focus on the results of red blood cell (RBC) deformability measurements as one of the most frequently studied non-adherent cells by on-chip methods. The relationship between mechanical properties and biological structures/features, as well as medical/diagnostic applications, are also discussed.

【 授权许可】

CC BY