Information Visualization to Enhance Sensitivity and Selectivity in Biosensing

Biointerphases

article

Osvaldo N. Oliveira¹  Felippe J. Pavinatto¹  Carlos J. L. Constantino²  Fernando V. Paulovich³  Maria Cristina F. de Oliveira³ 

[1] Instituto de Física de São Carlos, Universidade de São Paulo;Faculdade de Ciências e Tecnologia, UNESP Univ Estadual Paulista;Instituto de Ciências Matemáticas e de Computação, Universidade de São Paulo

关键词: Phytic Acid;    Partial Little Square Discriminant Analysis;    Electronic Nose;    Information Visualization;    Impedance Spectroscopy;   

DOI  :  10.1007/s13758-012-0053-7

学科分类：基础医学

来源: SpringerOpen

【 摘 要 】

An overview is provided of the various methods for analyzing biosensing data, with emphasis on information visualization approaches such as multidimensional projection techniques. Emphasis is placed on the importance of data analysis methods, with a description of traditional techniques, including the advantages and limitations of linear and non-linear methods to generate layouts that emphasize similarity/dissimilarity relationships among data instances. Particularly important are recent methods that allow processing high-dimensional data, thus taking full advantage of the capabilities of modern equipment. In this area, now referred to as e-science, the choice of appropriate data analysis methods is crucial to enhance the sensitivity and selectivity of sensors and biosensors. Two types of systems deserving attention in this context are electronic noses and electronic tongues, which are made of sensor arrays whose electrical or electrochemical responses are combined to provide “finger print” information for aromas and tastes. Examples will also be given of unprecedented detection of tropical diseases, made possible with the use of multidimensional projection techniques. Furthermore, ways of using these techniques along with other information visualization methods to optimize biosensors will be discussed.

【 授权许可】

CC BY