Rare diseases of bone: Erdheim-Chester and Rosai-Dorfman non-Langerhans cell histiocytoses

EFORT Open Reviews

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Andreas F. Mavrogenis¹  Vasilios G. Igoumenou¹  Thekla Antoniadou¹  Panayiotis D. Megaloikonomos¹  George Agrogiannis²  Periklis Foukas²  Sotirios G. Papageorgiou³ 

[1] First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine;Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine;Second Department of Internal Medicine, Hematology Unit, National and Kapodistrian University of Athens, School of Medicine

关键词: Erdheim-Chester disease;    Rosai-Dorfman disease;    juvenile xanthogranuloma;    non-juvenile xanthogranuloma;    non-Langerhans cell histiocytosis;    bone;   

DOI  :  10.1302/2058-5241.3.170047

学科分类：神经科学

来源: The British Editorial Society of Bone & Joint Surgery

【 摘 要 】

The accessory cells of the immune system consist of specialized dendritic cells (antigen-presenting) and various monocyte-macrophage (histiocytic) cell types (antigenprocessing cells). The neoplastic and systemic proliferation of these accessory cell types is particularly rare;1 additionally, until recently, because clonal markers were lacking, differentiation between a reactive and a neoplastic type of proliferation was difficult to establish.1 Accumulation and infiltration of variable numbers of monocytes, macrophages and dendritic cells in the affected tissues is associated with a group of diverse disorders named ‘histiocytoses’.

【 授权许可】

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