The role of alpha defensin in prosthetic joint infection (PJI) diagnosis: a literature review

EFORT Open Reviews

article

Tommaso Bonanzinga¹  Matteo Carlo Ferrari²  Piergiuseppe Tanzi³  Filippo Vandenbulcke⁵  Akos Zahar⁶  Maurilio Marcacci¹ 

[1] Humanitas University, Department of Biomedical Sciences, Italy.；Humanitas Clinical and Research Center;Humanitas Clinical and Research Center;IRCCS Istituto Ortopedico Rizzoli;Università di Bologna, Dipartimento Scienze Biomediche e Neuromotorie;Humanitas University, Department of Biomedical Sciences, Italy；Humanitas Clinical and Research Center;Helios ENDO-Klinik

关键词: alpha defensin;    PJI;    prosthetic joint infections;    synovial biomarkers;   

DOI  :  10.1302/2058-5241.4.180029

学科分类：神经科学

来源: The British Editorial Society of Bone & Joint Surgery

【 摘 要 】

Prosthetic joint infections (PJI) occur in 0.7% to 2.4% of patients and are responsible for 15% of failed total hip arthroplasties and 25% of revision total knee arthroplasties.1,2 Almost any microorganism can cause PJI, such as Gram-positive bacteria (accounting for about two-thirds of the total number of infections), Gram-negative bacteria and polymicrobic flora (accounting for about 10–15% of infections each), and fungi (rare).3–5 The management of infections is not standardized worldwide and the outcome is frequently unsatisfactory because of the increasing number of highly virulent and antibiotic-resistant bacteria, and due to an ageing patient population presenting with many comorbidities.

【 授权许可】

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