Total hip arthroplasty in sickle cell disease: a systematic review

EFORT Open Reviews

article

Eustathios Kenanidis¹  Konstantinos Kapriniotis²  Panagiotis Anagnostis¹  Michael Potoupnis¹  Panayiotis Christofilopoulos¹  Eleftherios Tsiridis¹ 

[1] Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Greece.；Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Greece；Hôpital de la Tour;Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center

关键词: avascular necrosis of femoral head;    SCD;    sickle cell disease;    sicklers;    THA;    total hip arthroplasty;    total hip replacement;   

DOI  :  10.1302/2058-5241.5.190038

学科分类：神经科学

来源: The British Editorial Society of Bone & Joint Surgery

【 摘 要 】

Sickle cell disease (SCD) is a common autosomal recessive disorder, caused by a point mutation in the b-globin chain of haemoglobin1. This hemoglobinopathy affects the shape of red blood cells that, under low oxygen tension, are susceptible to sickling and hence impede the blood supply to the human tissues.1,2 SCD has high mortality rates.3 The prevalence and severity of the disease are higher in some parts of the world such as Africa.4 SCD patients develop a variety of symptoms based on the severity of the disease. Anaemia, vaso-occlusive crises and chronic organ failure are the main features of SCD.2 Skeletal manifestations of SCD are also prevalent, including avascular necrosis (AVN) of the femoral head, osteoporosis, pathological fractures and infections, namely septic arthritis and osteomyelitis.2,5 Bony deformities such as marrow hyperplasia, thinning of trabeculae and cortices, as well as sclerotic areas that obliterate the femoral canal, are frequently encountered.

【 授权许可】

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