Morphologic correlates of the multimodal electromagnetic exposures efficiency (as exemplified by the experiment tumor growth)

Cardiometry

article

Tatiana A. Barteneva¹  Alla I. Shikhlyarova¹  Galina V. Zhukova¹  Tatiana P. Protasova¹  Marina I. Bragina¹  Elena A. Shirnina¹ 

[1] Rostov Research Institute of Oncology, Ministry of Healthcare of the Russian Federation

关键词: Electromagnetic exposure;    Anti-tumor effect;    Tumor infiltration;    Anti-stressor adaptation reaction;   

DOI  :  10.12710/cardiometry.2017.11.4853

学科分类：环境科学（综合）

来源: Russian New University

【 摘 要 】

Aims The aim of the present paper is to study the morphofunctional changes in the tumor tissue and peripheral zone in experimental animals under the influence of extremely high-frequency electromagnetic radiation (EHF EMR). Combined effect of EHF EMR and ultra-low-frequency magnetic field (ULF MF) without the use of special anti-tumor agents is to be studied as well. Materials and methods The experiments have been performed on 56 outbred male rats with inoculated sarcoma 45. Low intensity EHF EMR and ULF MF exposures have been carried out only on animals’ heads. Histological and morphometric study of the sarcoma 45 tumor tissue and its peripheral area has been performed. Results In case of the combined electromagnetic exposure (in 65 % of cases) against the background of the sTable anti-stressor adaptation reactions an evident anti-tumor effect has been observed. Under effective combined electromagnetic action, lymphocyte infiltration of the tumor tissue and its peripheral zone was enhanced not only in comparison with the reference group, but also compared to the EHF EMR monoexposure. Conclusions Thus, significant enhancement of the tumor tissue infiltration by leukocyte cells under the combined effect of EHF EMR and ULF MF may indicate mobilization of the local immune mechanisms due to the activation of the neuroendocrine and immune system organs.

【 授权许可】

CC BY