Mechanisms of electromagnetic influences and effects on membrane systems in neurons and cardiomyocytes

Cardiometry

article

Valery I. Orlov¹  Mikhail Y. Rudenko²  Alla I. Shikhlyarova³  Alexander A. Sukhov¹  Evgeniya Y. Kirichenko¹  Svetlana Y. Filippova¹  Vladimir A. Zernov²  Dmitry F. Makedonsky²  Konstantine K. Mamberger²  Sergey M. Rudenko² 

[1] Southern Federal University;Russian New University;Rostov Research Institute of Oncology, Ministry of Healthcare of the Russian Federation

关键词: Electromagnetic radiation;    Cardiomyocyte;    Neuron;    Action potential;    Membrane potential;    Ion channels;    Endogenous pacemaker activity;   

DOI  :  10.12710/cardiometry.2017.11.1727

学科分类：环境科学（综合）

来源: Russian New University

【 摘 要 】

Aim The aim of our studies was to discover responses of the membrane systems in neurons and cardiomyocytes as well as mechanisms of influences and effects produced by the broadband-spectrum stochastic electromagnetic radiation (BBSS EMR) on them according to data on membrane potential (MP) levels and action potential (AP) parameters obtained by us. Materials and methods Neurons from the isolated central neural system (CNS) of the snail Helix pomatia were selected to serve as a model for our experiments. We applied an electrophysiological technique implying recording of intracellular potentials of a neuron. The presented research work is of fundamental nature and reveals some intimate mechanisms of actions made by electromagnetic radiation (EMR) on the cytoplasm membrane of a neuron and its channels that is applicable to cardiomyocytes. An absolutely exclusive distinctive feature of our work is that the specific BBSS EMR used in our experiments has unique characteristics and offers broadband stochastic radiated frequencies in the range from 10n Hz to 10m Hz at an integral radiation power of only 0,1 µW. Another distinguishing feature of the applied EMR parameters is that the stochastically organized EMR is supplied under such action rhythms, which are close to the natural alpha-, theta- and delta-rhythms of an EEG as well to the natural background base resonance frequency of the Earth, which has been physically measured to be 7,83 Hz, that is evolutionary significant for biological systems. Results and discussion We are pioneers in the world science who succeeded in obtaining objective evidence for the effects made by the broadband-spectrum stochastic electromagnetic radiation (BBSS EMR) on intracellularly recorded electrophysiological properties of a CNS neuron. The used BBSS EMR was demonstrated to have the effects on the amplitude, the duration of an action potential and a membrane potential, following the pattern of a regulatory response to weak stimulation, similar to the reaction of training. The effects produced by BBSS EMR on the CNS neurons in the snail Helix pomatia are applicable to cardiomyocytes, since the electrophysiological and ionic mechanisms of firing an action potential and creating the required level of a membrane potential in these cells in the organism are identical; however they differ in their time parameters. Conclusions The regulation of the functional state of a neuron in the neuron network with the use of a non-invasive remote method of a control action has been objectively shown herein. According to our philosophy, a neuron is considered as an analogue of the formation of a transmembrane potential by a cardiomyocyte and at the same time as the basic model of the neural cellular auto-regulation of the phase-structured performance of the cardiovascular system. Adhering to this interpretation, a fine tuning instrument to control the functional state of a neuron, CNS, a cardiomyocyte or other cell systems in the organism has been discovered. It offers widest possibilities of a targeted fine-tuning regulation of the control systems in a human organism.

【 授权许可】

CC BY