Correction of the functional state of female rats after unilateral ovariectomy using a succinate containing composition

Cardiometry

article

Anna A. Vasilieva¹  Maria A. Simonova¹  Alekber A. Bairamov²  Elena V. Grishina¹  Mikhail L. Uchitel¹  Eugene I. Maevsky¹ 

[1] Institute of Theoretical and Experimental Biophysics RAS, Institutskaya str. 3;The Federal Almazov North-West Medical Research Centre, the Ministry of Health of the Russian Federation

关键词: Unilateral ovariectomy;    Succinate containing composition;    Estrous cycle;    Stress;    Cytobiochemical analysis;   

DOI  :  10.12710/cardiometry.2017.8692

学科分类：环境科学（综合）

来源: Russian New University

【 摘 要 】

Unilateral ovariectomy (UOE) of female rats caused an increase in duration of the non-reproductive period (NRP) – metestrus and diestrus phases, and shortening of the reproductive period (RP) – proestrus and estrus phases of the estrous cycle (a symptom of hormonal deficiency). Signs of stress persisted 5 weeks after UOE: reduction of the ratio of thymus weight to the weight of adrenal glands (T/A). A two-week course of the succinate-containing composition with added B vitamins (SCCV) administered to the control female rats and those upon UOE has increased the T/A ratio as compared to that of intact animals, which is an indication of “activation” according to Garkavi et al. [1] and restored the NRP/RP ratio. Cytobiochemical analysis found a significant increase in nitroblue tetrazolium reduction during succinate oxidation in lymphocytes according to reading of animal blood smears.

【 授权许可】

CC BY