Comparing lesion detection efficacy and image quality across different PET system generations to optimize the iodine-124 PET protocol for recurrent thyroid cancer

EJNMMI Physics

Walter Jentzen¹  Ken Herrmann¹  Pedro Fragoso Costa¹  Wolfgang Peter Fendler¹  David Kersting¹  Christoph Rischpler¹  Miriam Sraieb¹  Michael Nader¹  Manuel Weber¹  Gerald Antoch²  Maurizio Conti³  Lale Umutlu⁴ 

[1] Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany;West German Cancer Center (WTZ), Essen, Germany;German Cancer Consortium (DKTK), Essen and Dusseldorf, Germany;German Cancer Consortium (DKTK), Essen and Dusseldorf, Germany;Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, 40225, Dusseldorf, Germany;Siemens Medical Solutions USA, Inc., Knoxville, TN, USA;West German Cancer Center (WTZ), Essen, Germany;German Cancer Consortium (DKTK), Essen and Dusseldorf, Germany;Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, 45147, Essen, Germany;

关键词: Iodine-124 PET;    Digital PET/CT;    Biograph Vision;    Detectability;    Differentiated thyroid cancer;   

DOI  :  10.1186/s40658-021-00361-y

来源: Springer

【 摘 要 】

BackgroundIn recurrent differentiated thyroid cancer patients, detectability in 124I PET is limited for lesions with low radioiodine uptake. We assess the improvements in lesion detectability and image quality between three generations of PET scanners with different detector technologies. The results are used to suggest an optimized protocol.MethodsDatasets of 10 patients with low increasing thyroglobulin or thyroglobulin antibody levels after total thyroidectomy and radioiodine therapies were included. PET data were acquired and reconstructed on a Biograph mCT PET/CT (whole-body, 4-min acquisition time per bed position; OSEM, OSEM-TOF, OSEM-TOF+PSF), a non-TOF Biograph mMR PET/MR (neck region, 4 min and 20 min; OSEM), and a new generation Biograph Vision PET/CT (whole-body, 4 min; OSEM, OSEM-TOF, OSEM-TOF+PSF). The 20-min image on the mMR was used as reference to calculate the detection efficacy in the neck region. Image quality was rated on a 5-point scale.ResultsAll detected lesions were in the neck region. Detection efficacy was 8/9 (Vision OSEM-TOF and OSEM-TOF+PSF), 4/9 (Vision OSEM), 3/9 (mMR OSEM and mCT OSEM-TOF+PSF), and 2/9 (mCT OSEM and OSEM-TOF). Median image quality was 4 (Vision OSEM-TOF and OSEM-TOF+PSF), 3 (Vision OSEM, mCT OSEM-TOF+PSF, and mMR OSEM 20-min), 2 (mCT OSEM-TOF), 1.5 (mCT OSEM), and 1 (mMR OSEM 4 min).ConclusionAt a clinical standard acquisition time of 4 min per bed position, the new generation Biograph Vision using a TOF-based image reconstruction demonstrated the highest detectability and image quality and should, if available, be preferably used for imaging of low-uptake lesions. A prolonged acquisition time for the mostly affected neck region can be useful.

【 授权许可】

CC BY