Sequential filtering for clinically relevant variants as a method for clinical interpretation of whole exome sequencing findings in glioma

BMC Medical Genomics

O. Uğur Sezerman¹  Ege Ülgen¹  Kaya Bilguvar²  Cemaliye Akyerli Boylu³  Şirin Kılıçturgay Yüksel³  Özge Can⁴  M. Cengiz Yakıcıer⁵  M. Necmettin Pamir⁶  Koray Özduman⁶  Ayça Erşen Danyeli⁷ 

[1] Department of Biostatistics and Medical Informatics, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey;Department of Genetics, School of Medicine, Yale University, New Haven, CT, USA;Yale Center for Genome Analysis, West Haven, CT, USA;Department of Medical Biology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey;Department of Medical Engineering, Faculty of Engineering, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey;Department of Molecular Biology, School of Arts and Sciences, Acibadem Mehmet Ali Aydinlar University Istanbul, Istanbul, Turkey;Department of Neurosurgery, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Altunizade Mahallesi, Yurtcan Sok. No:1, 34662, Üsküdar, Istanbul, Turkey;Department of Pathology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey;

关键词: Whole exome sequencing;    NGS;    Glioma;    Brain tumor;    Clinical analysis;   

DOI  :  10.1186/s12920-021-00904-3

来源: Springer

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