Mechanism of mesenchymal stem cells in spinal cord injury repair through macrophage polarization

Cell & Bioscience

Meiying Li¹  Lisha Li¹  Hao Wu²  Jiaxu Yang²  Shengfeng Sun²  Hequn Wang²  Nan An³ 

[1] The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, 126 Xinmin Street, 130021, Changchun, Jilin, People’s Republic of China;The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, 126 Xinmin Street, 130021, Changchun, Jilin, People’s Republic of China;The First Hospital of Jilin University, 130021, Changchun, Jilin, China;The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, 126 Xinmin Street, 130021, Changchun, Jilin, People’s Republic of China;The Second Hospital of Jilin University, 130021, Changchun, Jilin, China;

关键词: Spinal cord injury;    Inflammatory microenvironment;    Macrophage polarization;    Mesenchymal stem cells;   

DOI  :  10.1186/s13578-021-00554-z

来源: Springer

【 摘 要 】

Treatment and rehabilitation of spinal cord injury (SCI) is a major problem in clinical medicine. Modern medicine has achieved minimal progress in improving the functions of injured nerves in patients with SCI, mainly due to the complex pathophysiological changes that present after injury. Inflammatory reactions occurring after SCI are related to various functions of immune cells over time at different injury sites. Macrophages are important mediators of inflammatory reactions and are divided into two different subtypes (M1 and M2), which play important roles at different times after SCI. Mesenchymal stem cells (MSCs) are characterized by multi-differentiation and immunoregulatory potentials, and different treatments can have different effects on macrophage polarization. MSC transplantation has become a promising method for eliminating nerve injury caused by SCI and can help repair injured nerve tissues. Therapeutic effects are related to the induced formation of specific immune microenvironments, caused by influencing macrophage polarization, controlling the consequences of secondary injury after SCI, and assisting with function recovery. Herein, we review the mechanisms whereby MSCs affect macrophage-induced specific immune microenvironments, and discuss potential avenues of investigation for improving SCI treatment.

【 授权许可】

CC BY