Cerebellar transcranial direct current stimulation reconfigurates static and dynamic functional connectivity of the resting-state networks

Cerebellum & Ataxias

F. Grami¹  G. de Marco¹  C. Habas²  M. Manto³  F. Bodranghien⁴ 

[1]Laboratoire LINP2 « Laboratoire Interdisciplinaire de Neurosciences, Physiologie et Psychologie : Activité physique, Santé et Apprentissages», UPL, Université Paris Nanterre, Nanterre, France

[2]Service de Neuroimagerie, Centre Hospitalier National d’Ophtalmologie des 15-20, Quinze-Vingt, 28, rue de Charenton, 75012, Paris, France

[3]Services de Neurosciences, UMons, 7000, Mons, Belgium

[4]Unité des Ataxies Cérébelleuses, Service de Neurologie, CHU-Charleroi, 6000, Charleroi, Belgium

[5]Unité d’Etude du Mouvement GRIM, FNRS, ULB-Erasme, Route de Lennik, Bruxelles, Belgium

关键词: Transcranial direct stimulation;    Cerebellum;    Resting-state;    Functional connectivity;    Dynamics;    Limbic network;    Salience network;    Default-mode network;   

DOI  :  10.1186/s40673-021-00132-6

来源: Springer

【 摘 要 】

BackgroundTranscranial direct current stimulation (tDCS) of the cerebellum dynamically modulates cerebello-thalamo-cortical excitability in a polarity-specific manner during motor, visuo- motor and cognitive tasks. It remains to be established whether tDCS of the cerebellum impact also on resting-state intrinsically connected networks (ICNs). Such impact would open novel research and therapeutical doors for the neuromodulation of ICNs in human.MethodWe combined tDCS applied over the right cerebellum and fMRI to investigate tDCS- induced resting-state intrinsic functional reconfiguration, using a randomized, sham-controlled design. fMRI data were recorded both before and after real anodal stimulation (2 mA, 20 min) or sham tDCS in 12 right-handed healthy volunteers. We resorted to a region-of-interest static correlational analysis and to a sliding window analysis to assess temporal variations in resting state FC between the cerebellar lobule VII and nodes of the main ICNs.ResultsAfter real tDCS and compared with sham tDCS, functional changes were observed between the cerebellum and ICNs. Static FC showed enhanced or decreased correlation between cerebellum and brain areas belonging to visual, default-mode (DMN), sensorimotor and salience networks (SN) (p-corrected < 0.05). The temporal variability (TV) of BOLD signal was significantly modified after tDCS displaying in particular a lesser TV between the whole lobule VII and DMN and central executive network and a greater TV between crus 2 and SN. Static and dynamic FC was also modified between cerebellar lobuli.ConclusionThese results demonstrate short- and long-range static and majorly dynamic effects of tDCS stimulation of the cerebellum affecting distinct resting-state ICNs, as well as intracerebellar functional connectivity, so that tDCS of the cerebellum appears as a non-invasive tool reconfigurating the dynamics of ICNs.

【 授权许可】

CC BY