Thalamus and claustrum control parallel layer 1 circuits in retrosplenial cortex

eLife

Sameer Kailasa¹  Izabela Jedrasiak-Cape²  Shyam Kumar Sudhakar²  Sharena P Rice³  Ellen KW Brennan³  Omar J Ahmed⁴ 

[1] Department of Mathematics, University of Michigan, Ann Arbor, United States;Department of Psychology, University of Michigan, Ann Arbor, United States;Department of Psychology, University of Michigan, Ann Arbor, United States;Neuroscience Graduate Program, University of Michigan, Ann Arbor, United States;Department of Psychology, University of Michigan, Ann Arbor, United States;Neuroscience Graduate Program, University of Michigan, Ann Arbor, United States;Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, United States;Kresge Hearing Research Institute, University of Michigan, Ann Arbor, United States;Department of Biomedical Engineering, University of Michigan, Ann Arbor, United States;

关键词: retrosplenial cortex;    thalamus;    claustrum;    head direction;    spatial orientation;    angular head velocity;    Mouse;   

DOI  :  10.7554/eLife.62207

来源: eLife Sciences Publications, Ltd

【 摘 要 】

The granular retrosplenial cortex (RSG) is critical for both spatial and non-spatial behaviors, but the underlying neural codes remain poorly understood. Here, we use optogenetic circuit mapping in mice to reveal a double dissociation that allows parallel circuits in superficial RSG to process disparate inputs. The anterior thalamus and dorsal subiculum, sources of spatial information, strongly and selectively recruit small low-rheobase (LR) pyramidal cells in RSG. In contrast, neighboring regular-spiking (RS) cells are preferentially controlled by claustral and anterior cingulate inputs, sources of mostly non-spatial information. Precise sublaminar axonal and dendritic arborization within RSG layer 1, in particular, permits this parallel processing. Observed thalamocortical synaptic dynamics enable computational models of LR neurons to compute the speed of head rotation, despite receiving head direction inputs that do not explicitly encode speed. Thus, parallel input streams identify a distinct principal neuronal subtype ideally positioned to support spatial orientation computations in the RSG.

【 授权许可】

CC BY