Scaling of subcellular actin structures with cell length through decelerated growth

eLife

Bruce L Goode¹  Shane G McInally²  Jane Kondev³ 

[1] Department of Biology, Brandeis University, Waltham, United States;Department of Biology, Brandeis University, Waltham, United States;Department of Physics, Brandeis University, Waltham, United States;Department of Physics, Brandeis University, Waltham, United States;

关键词: actin;    scaling;    size control;    S. cerevisiae;   

DOI  :  10.7554/eLife.68424

来源: eLife Sciences Publications, Ltd

【 摘 要 】

How cells tune the size of their subcellular parts to scale with cell size is a fundamental question in cell biology. Until now, most studies on the size control of organelles and other subcellular structures have focused on scaling relationships with cell volume, which can be explained by limiting pool mechanisms. Here, we uncover a distinct scaling relationship with cell length rather than volume, revealed by mathematical modeling and quantitative imaging of yeast actin cables. The extension rate of cables decelerates as they approach the rear of the cell, until cable length matches cell length. Further, the deceleration rate scales with cell length. These observations are quantitatively explained by a ‘balance-point’ model, which stands in contrast to limiting pool mechanisms, and describes a distinct mode of self-assembly that senses the linear dimensions of the cell.

【 授权许可】

CC BY