Interplay between severities of COVID-19 and the gut microbiome: implications of bacterial co-infections?

Gut Pathogens

Jyoti Chhibber-Goel¹  Amit Sharma¹  Sreehari Gopinathan¹ 

[1] Molecular Medicine Group, International Center for Genetic Engineering and Biotechnology, New Delhi, India;

关键词: Angiotensin-converting enzyme 2;    Gut-lung axis;    Gut-microbiome;    Opportunistic pathogens;    Probiotics;    SARS-CoV-2;   

DOI  :  10.1186/s13099-021-00407-7

来源: Springer

【 摘 要 】

COVID-19 is an acute respiratory distress syndrome and is often accompanied by gastrointestinal symptoms. The SARS-CoV-2 has been traced not only in nasopharyngeal and mid-nasal swabs but also in stool and rectal swabs of COVID-19 patients. The gut microbiota is important for an effective immune response as it ensures that unfavorable immune reactions in lungs and other vital organs are regulated. The human gut-lung microbiota interplay provides a framework for therapies in the treatment and management of several pulmonary diseases and infections. Here, we have collated data from COVID-19 studies, which suggest that bacterial co-infections as well as the gut-lung cross talk may be important players in COVID-19 disease prognosis. Our analyses suggests a role of gut microbiome in pathogen infections as well as in an array of excessive immune reactions during and post COVID-19 infection recovery period.

【 授权许可】

CC BY