Vitamin D status and blood pressure in children and adolescents: a systematic review of observational studies

Systematic Reviews

Dimitrios Papandreou¹  Fatme Al Anouti¹  Myriam Abboud¹  Rana Rizk²  Suzan Haidar³  Nadine Mahboub⁴ 

[1] Department of Health, College of Natural and Health Sciences, Zayed University, Dubai, United Arab Emirates;Institut National de Santé Publique, d’Épidémiologie Clinique et de Toxicologie (INSPECT-Lb), Beirut, Lebanon;Lebanese International University, Beirut, Lebanon;Lebanese International University, Beirut, Lebanon;Maastricht University, Maastricht, The Netherlands;

关键词: Vitamin D;    Blood pressure;    Children;    Adolescents;    Systematic review;   

DOI  :  10.1186/s13643-021-01584-x

来源: Springer

【 摘 要 】

BackgroundChildhood hypertension is a growing public health problem. Simultaneously, hypovitaminosis D is widespread in this population and could be associated with hypertension. This study systematically reviewed the literature on the relationship between vitamin D status and blood pressure (BP) in children and adolescents.MethodsFollowing the PRISMA guidelines, PUBMED, MEDLINE, CINAHL, EMBASE, Cochrane Library, and ClinicalTrials.gov and the gray literature without language or time restrictions were searched. We included observational studies, assessed their risk of bias, and extracted data on population characteristics, vitamin D status and BP measurements, and the association between the two variables. A narrative analysis of the studies was performed.ResultsIn total, 85 studies were included. Prospective cohort studies showed no association between vitamin D and BP, and generally, they were flawed. Also, the majority of non-prospective cohort studies (cross-sectional, retrospective, case-control) did not report an association between vitamin D and BP. They were mostly flawed regarding BP measurement and adjusting to potential confounders.ConclusionThe results on the relationship between vitamin D status and BP in children and adolescents varied between the studies, and mainly pointed towards lack of association.

【 授权许可】

CC BY