An edge-based statistical analysis of long non-coding RNA expression profiles reveals a negative association between Parkinson’s disease and colon cancer

BMC Medical Genomics

Mingyue Zhang¹  Zhiming Ma²  Suyan Tian³ 

[1] Department of Gastroenterology, First Hospital of Jilin University, 1 Xinmin Street, 130021, Changchun, Jilin, People’s Republic of China;Department of Gastrointestinal Nutrition and Hernia Surgery, Second Hospital of Jilin University, 218 Ziqiang Road, 130041, Changchun, Jilin, People’s Republic of China;Division of Clinical Research, First Hospital of Jilin University, 1 Xinmin Street, 130021, Changchun, Jilin, People’s Republic of China;

关键词: Colon cancer;    Parkinson’s disease;    Long non-coding RNA (lncRNA);    Weighted gene co-expression network (WGCNA);    Edge;    Association;   

DOI  :  10.1186/s12920-021-00882-6

来源: Springer

【 摘 要 】

BackgroundColon cancer (CC) is one of the most common malignant tumors, while Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Recent accumulating evidence indicates that these two diseases are associated with each other. Also, from the perspective of long non-coding RNAs, some well-known genes such as H19 and PVT1 can link these two diseases together. Several studies have shown that patients with PD had a decreased risk of developing CC compared with patients without PD. However, controversies surround the relationship between PD and CC, and to date, no concordant conclusion has been drawn.MethodsIn this study, we aimed to assess the association between these two diseases based on lncRNA-to-lncRNA interactions. Motivated by the weighted gene co-expression network analysis method, a customized procedure was proposed and used to identify differentially correlated edges (DCEs) in the respective interaction networks for PD and CC and explore how these two diseases are linked.ResultsOf the two sets of DCEs for PD and CC, 16 pairs overlapped. Among them, 15 edges had opposite signs, with positive signs for CC indicating a gain of connectivity, whereas negative signs for PD indicating a loss of connectivity.ConclusionsBy using the lncRNA expression profiles, and a customized procedure, an answer to the question about how PD and CC are associated is provided.

【 授权许可】

CC BY